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Publications

2024

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  • Akdemir B, Gungor MZ, Senturk S. RUVBL1/2 Complex in Cancer: Emerging Mechanisms and Therapeutic Opportunities, Interdisciplinary Cancer Research (pp.1-24), Londrina: Springer, Cham. 

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  • Erdal E, Karabicici M, Akbari S, Calıskan C, Celiker C, Oz O, Binokay L, Karakulah G, Senturk S. Fibrotic Phenotype in CRISPR knockout p53 of Hepatic Organoids within a Pro-Carcinogenic Microenvironment, Research Square Platform LLC, 2024. doi:10.21203/rs.3.rs-3935080/v1

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  • Cakiroglu E, Senturk S. CRISPR/Cas9 Therapy in Cancer Treatment, Turkiye Klinikleri Medical Biology-Special Topics 2 (2), 44-52.

 

2023​

 

  • Ozgun G, Yaras T, Landman N, Karakulah G, van Lohuizen MM, Senturk S, Erkek Ozhan S, Retinoids and EZH2 inhibitors cooperate to orchestrate cytotoxic effects on bladder cancer cells, bioRxiv. 2023:2023-04. doi: https://doi.org/10.1101/2023.04.19.537500.

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  • Akbaba H, Erel-Akbaba G, Baspinar Y, and Senturk S, Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders, ACS Omega 2023 8 (48), 46101-46112. doi:10.1021/acsomega.3c07138.

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  • Gungor Y, Gonul C.P, Senturk S. Structure and Function of the H19 Long Non-coding RNA in Cancer.  Interdisciplinary Cancer Research, Springer. 2023:1-27. doi:10.1007/16833-2023-177.

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  • Atalay EB, Senturk S, Kayali HA. Wild-type IDH1 Knockout Leads to G0/G1 Arrest, Impairs Cancer Cell Proliferation, Altering Glycolysis, and the TCA Cycle in Colon Cancer. Biochemical genetics. 2023 January . doi:10.1007/s10528-022-10325-1. 

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  • Kurden-Pekmezci A, Cakiroglu E, Eris S, Mazi FA, Coskun-Deniz OS, Dalgic E, Oz O, Senturk S. MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth. Life Sci. 2023 Jun 15;323:121690. doi: 10.1016/j.lfs.2023.121690. Epub 2023 Apr 13. 

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  • Kalyoncu S, Yilmaz S, Kuyucu AZ, Sayili D, Mert O, Soyturk H, Gullu S, Akinturk H, Citak E, Arslan M, Taskinarda MG, Tarman IO, Altun GY, Ozer C, Orkut R, Demirtas A, Tilmensagir I, Keles U, Ulker C, Aralan G, Mercan Y, Ozkan M, Caglar HO, Arik G, Ucar MC, Yildirim M, Yildirim TC, Karadag D, Bal E, Erdogan A, Senturk S, Uzar S, Enul H, Adiay C, Sarac F, Ekiz AT, Abaci I, Aksoy O, Polat HU, Tekin S, Dimitrov S, Ozkul A, Wingender G, Gursel I, Ozturk M, Inan M. Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris. Sci Rep. 2023 Mar 30;13(1):5224. doi: 10.1038/s41598-023-32021-9.

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  • Atalay EB, Senturk S, Kayali HA. Wild-type IDH1 Knockout Leads to G0/G1 Arrest, Impairs Cancer Cell Proliferation, Altering Glycolysis, and the TCA Cycle in Colon Cancer. Biochemical genetics. 2023 January. doi:10.1007/s10528-022-10325-1.

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  • Özden-Yılmaz G, Savas B, Bursalı A, Eray A, Arıbaş A, Senturk S, Karaca E, Karakülah G, Erkek-Ozhan S. Differential Occupancy and Regulatory Interactions of KDM6A in Bladder Cell Lines. Cells. 2023 Mar 8;12(6):836. doi: 10.3390/cells12060836.

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  • Guneri-Sozeri PY, Özden-Yılmaz G, Kisim A, Cakiroglu E, Eray A, Uzuner H, Karakülah G, Pesen-Okvur D, Senturk S, Erkek-Ozhan S. FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer. Commun Biol 6, 199 (2023). doi:10.1038/s42003-023-04561-3

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  • Mazi FA, Cakiroglu E, Uysal M, Kalyoncu M, Demirci D, Sozeri PYG, Yilmaz GO, Ozhan SE, Senturk S. The paracaspase MALT1 is a downstream target of Smad3 and potentiates the crosstalk between TGF-β and NF-kB signaling pathways in cancer cells.. Cellular signalling. 2023 January; 105: 110611. doi:10.1016/j.cellsig.2023.110611.

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2022​

 

  • Dayanc, B., Eris, S., Senturk, S. (2022). Challenges in First-Line Osimertinib Therapy in EGFR-Mutant Non-small Cell Lung Cancer: Acquired Resistance Is the Issue. In: Interdisciplinary Cancer Research. Springer, Cham. doi.org/10.1007/16833_2022_54

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  • Yagmur Toktay, Bengisu Dayanc, Serif Senturk. Engineering and validation of a dual luciferase reporter system for quantitative and systematic assessment of regulatory sequences in Chinese hamster ovary cells. Sci Rep. 2022 Apr 11;12(1):6050. doi: 10.1038/s41598-022-09887-2.

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  • Medine Zeynep Gungor, Merve Uysal, Serif Senturk. The Bright and the Dark Side of TGF-β Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications. Cancers. 2022 February. doi: 10.3390/cancers14040940

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2021

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  • Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaja Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Larry Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J. Hannon, Raffaella Sordella. An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKI resistant cells by modulating miR-335 expression. eLife. 2021 July. doi:10.7554/eLife.66109.

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2020

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2019

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2018

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2017

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2016

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  • Shirole NH, Pal D, Kastenhuber ER, Senturk S, Boroda J, Pisterzi P, Miller M, Munoz G, Anderluh M, Ladanyi M, Lowe SW, Sordella R. TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions. eLife. 2016 October; 5. doi:10.7554/eLife.17929.

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2015

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  • Nowak DG, Cho H, Herzka T, Watrud K, DeMarco DV, Wang VM, Senturk S, Fellmann C, Ding D, Beinortas T, Kleinman D, Chen M, Sordella R, Wilkinson JE, Castillo-Martin M, Cordon-Cardo C, Robinson BD, Trotman LC. MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. Cancer discovery. 2015 June; 5 (6): 636-51. doi:10.1158/2159-8290.CD-14-1113.

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2014

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  • Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh AM, Nemajerova A, Lazzara MJ, Altorki NK, Krainer A, Moll UM, Lowe SW, Cartegni L, Sordella R. p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proceedings of the National Academy of Sciences of the United States of America. 2014 August; 111 (32): E3287-96. doi:10.1073/pnas.1321640111.

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2013

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  • Mender I, Senturk S, Ozgunes N, Akcali KC, Kletsas D, Gryaznov S, Can A, Shay JW, Dikmen ZG. Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton. International journal of oncology. 2013 May; 42 (5): 1709-15. doi:10.3892/ijo.2013.1865.

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2011

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  • Sucularli C, Senturk S, Ozturk M, Konu O. Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment. Molecular biology reports. 2011 August; 38 (6): 4111-23. doi:10.1007/s11033-010-0531-2.

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  • Buontempo F, Ersahin T, Missiroli S, Senturk S, Etro D, Ozturk M, Capitani S, Cetin-Atalay R, Neri ML. Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status. Investigational new drugs. 2011 December; 29 (6): 1303-13. doi:10.1007/s10637-010-9486-3.

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2010

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  • Mumcuoglu M, Bagislar S, Yuzugullu H, Alotaibi H, Senturk S, Telkoparan P, Gur-Dedeoglu B, Cingoz B, Bozkurt B, Tazebay UH, Yulug IG, Akcali KC, Ozturk M. The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity. PloS one. 2010 June; 5 (6): e11288. doi:10.1371/journal.pone.0011288.

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  • Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, Ozturk M. Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology (Baltimore, Md.). 2010 September; 52 (3): 966-74. doi:10.1002/hep.23769.

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2009

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  • Yuzugullu H, Benhaj K, Ozturk N, Senturk S, Celik E, Toylu A, Tasdemir N, Yilmaz M, Erdal E, Akcali KC, Atabey N, Ozturk M. Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Molecular cancer. 2009 October; 8: 90. doi:10.1186/1476-4598-8-90.

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  • Ozturk M, Arslan-Ergul A, Bagislar S, Senturk S, Yuzugullu H. Senescence and immortality in hepatocellular carcinoma. Cancer letters. 2009 December; 286 (1): 103-13. doi:10.1016/j.canlet.2008.10.048. 

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2006

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  • Ozturk N, Erdal E, Mumcuoglu M, Akcali KC, Yalcin O, Senturk S, Arslan-Ergul A, Gur B, Yulug I, Cetin-Atalay R, Yakicier C, Yagci T, Tez M, Ozturk M. Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells. Proceedings of the National Academy of Sciences of the United States of America. 2006 February; 103 (7): 2178-83. doi:10.1073/pnas.0510877103.

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Book Chapters

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  • CRISPR/Cas9 Gene Editing in Mammalian Cells Using LentiCRISPRv2/LentiGuide-Puro Vectors (2021). CRISPR-Cas Methods. Springer Protocols.

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  • Inducible CRISPR-based Genome Editing for the Characterization of Cancer Genes (2018). Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery. Cambridge University Press.

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Total: 2 (Updated 13/04/2022)

 
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